ANTIBODIES FOR DIAGNOSIS AND TREATMENT OF FLAVIVIRAL INFECTIONS

摘要

We describe an immunoglobulin capable of binding to a dengue envelope glycoprotein (E) polypeptide, in which the immunoglobulin is capable of binding to an epitope bound by antibody 9Fl 2, or a variant, homologue, derivative or fragment thereof. The epitope may comprise residues K305, K307, K310 and G330 of a dengue envelope glycoprotein (E) sequence, with reference to the position numbering shown as SEQ ID NO: 2. The immunoglobulin may comprise the variable region of monoclonal antibody 9Fl 2 (SEQ ID NO: 4, SEQ ID NO: 6).