NMNAT2 MODULATOR

摘要

The present invention relates to anNmnat2 modulator useful as a neuroprotective medicament in the treatment of neurodegenerative disorders, in particular but not exclusively disorders involving Wallerian degeneration of neuronal tissue, to the use of Nmnat2 as a biomarker for Wallerian degeneration, to a method of demonstrating Wallerian degeneration using an Nmnat2-based biomarker, to a diagnostic kit for detecting Wallerian degeneration, to a method of screening for an Nmnat2 modulator, and to an Nmnat2 modulator identified using the aforementioned screening method.