BRAIN TUMOR STEM CELL DIFFERENTIATION PROMOTER, AND THERAPEUTIC AGENT FOR BRAIN TUMOR
摘要
<p>Disclosed is a pharmaceutical preparation which can reduce the tumorigenicity of a glioma stem cell that has resistance against anti-cancer agents and radioactive rays and can increase the sensitivity of the glioma stem cell to anti-cancer agents and radioactive rays. Specifically disclosed is a glioma stem cell differentiation promoter which comprises a substance capable of inhibiting a TGF-ß-Sox4-Sox2 pathway, i.e., a pathway through which TGF-ß can induce the expression of Sox4 and through which Sox4 can promote the expression of Sox2, in the glioma stem cell.</p>
申请公布号
WO2010092974(A1)
申请公布日期
2010.08.19
申请号
WO2010JP51950
申请日期
2010.02.10
申请人
THE UNIVERSITY OF TOKYO;MIYAZONO, KOHEI;IKUSHIMA, HIROAKI;MIYAZAWA, KEIJI;TODO, TOMOKI;INO, YASUSHI