IgG-Fc FRAGMENT AND PROCESS FOR PRODUCING SAME

摘要

Disclosed is a full-length IgG-Fc fragment having a substantially homogeneous sugar chain added thereto. Also disclosed is a process for producing the full-length IgG-Fc fragment. Specifically disclosed is an IgG-Fc fragment having a sugar chain added thereto, in which the sugar chain is added to the same position as that in a naturally occurring IgG-Fc fragment, any one amino acid residue selected from 1st to 30th amino acid residues from the sugar chain-added amino acid residue on the N-terminal side of the sugar chain-added amino acid residue is substituted by a Cys residue and at least one Met residue is substituted by an amino acid residue other than a Met residue. Also specifically disclosed is a process for producing the IgG-Fc fragment.