DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF.

摘要

The invention relates to compounds of the formula (I) in which: A is a bond, an oxygen atom, or a -0-CH2- group; Ar1 is a phenyl or heteroaryl group; Ar2 is a phenyl, heteroaryl or heterocycloalkyl group; R1a,b,c and R2a,b,c are a hydrogen or halogen atom or an alkyl, cycloalkyl, -alkyl-cycloalkyl group optionally substituted by one or more halogen atoms, -OR5 (hydroxy ou alkoxy), hydroxy- alkyl, alkoxy-alkyl, alkoxy-alkoxy, halogenoalkyl, -O-halogenoalkyl, oxo, -CO- alkyl, -CO-alkyl-NR6R7, -CO-halogenoalkyl, -COOR5, alkyl-COOR5, -O-alkyl- COOR5, -SO2-alkyl, -SO2-cycloalkyl, -SO2-alkyl-cycloalkyl, -SO2-alkyl-OR5, -SO2- alkyl-COOR5, -SO2-alkyl-NR6R7 -S02-halogenoalkyl, alkyl-S02-alkyl, -SO2-NR6R7, - SO2-alkyl-O-alkyl-OR5, -CONR6R7, -alkyl-CONR6R7 or -O-alkyl-NR6R7, or R1a R 1b, R 1c are respectively bonded to R2a, R2b, R 2c and to the carbon atom bearing them and represent -O-alkyl-0-; R3 is a hydrogen atom or an alkyl group; R4 is a hydrogen or halogen atom or a cyano group, -OR5, hydroxy-alkyl, -COOR5, -NR6R7, -CONR6R7, -SO2-alkyl or -SO2-NR6R7, -NR6- COOR5, -NR6-COR5, -CO-NR6-alkyl-OR5;; R5, R6 and R7 are a hydrogen atom, an alkyl or –alkyl-phenyl group; and R8 is a hydrogen atom, a -SO2-alkyl group or a group of the formula –B-Het in which B can be absent or represents a bond, an oxygen atom or a -CO- ou -SO2- (CH2)n group with n equal to 0, 1 or 2, and Het is a heteroaryl or heterocycloalkyl optionally substituted by alkyl, -SO2-alkyl and - COOR5 groups. The invention also relates to a method for making the same and to the therapeutic application thereof.