| 摘要 |
The present invention provides a method of screening for compounds which affect the processing of EphA7 by ³-secretase, comprising the following steps:
(i) contacting a first biological composition containing ³-secretase or a biologically active fragment thereof with a second biological composition containing EphA7 in the presence and absence of a candidate compound;
(ii) measuring the cleavage of the EphA7 in the presence and absence of the candidate compound;
(iii) selecting those candidate compounds which affect the cleavage of the EphA7 by ³-secretase; and
(iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA7 by ³-secretase.
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