发明名称 |
METHODS FOR SELECTING PROTEASE RESISTANT POLYPEPTIDES |
摘要 |
The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g. for treating disease in humans. |
申请公布号 |
WO2010063818(A3) |
申请公布日期 |
2010.08.12 |
申请号 |
WO2009EP66395 |
申请日期 |
2009.12.04 |
申请人 |
GLAXO GROUP LIMITED;ENEVER, CAROLYN;JESPERS, LAURENT;PUPECKA, MALGORZATA;TOMLINSON, IAN M |
发明人 |
ENEVER, CAROLYN;JESPERS, LAURENT;PUPECKA, MALGORZATA;TOMLINSON, IAN M |
分类号 |
C07K16/00;C12Q1/37 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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