INSULIN-LIKE GROWTH FACTOR SIGNALING AND INTEGRIN

摘要

The present invention resides in the discovery that the specific interaction between insulin-like growth factor 1 (IGFl) and integrin is involved in integrin-mediated cellular signaling, such as enhanced proliferation of cells expressing integrin, especially integrin avß3, a6ß1 and a6ß4. Thus, this invention provides for a novel method for inhibiting integrin signaling by using an inhibitor of IGFl -integrin binding. A method for identifying inhibitors of IGFl -integrin binding is also described. Further disclosed are polypeptides, nucleic acids, and corresponding compositions for inhibiting integrin signaling.