Poly-epitope peptide derived from thymidylate synthase having immunological and anti-tumour activity

摘要

Provided is a multiepitope peptide, for medical use, consisting of amino acids 1 to 9; amino acids 10 to 18; and amino acids 19 to 27 of a specified sequence, wherein the groups can be combined in any order. Further provided is the peptide consisting in the sequence YMIAHITGLFLDSLGFSTTLGDAHIYL. Further provided are corresponding expression vectors and methods of obtaining in vitro cytotoxic T lymphocytes using the materials and use of such lymphocytes in immunotherapy.