Methods and compositions for post-transcriptional gene silencing

摘要

An isolated double stranded ribonucleic acid (dsRNA) molecule that inhibits the expression of a target gene, the dsRNA comprising two strands of nucleotides wherein a first strand has a length of from 19 to 28 consecutive nucleotides and is substantially identical to a sequence in the target gene and wherein a second strand is substantially complementary to the first strand, and a binding moiety that binds a 3′ end of the first strand to a 5′ end of the second strand. An isolated double stranded ribonucleic acid molecule comprising a first strand of nucleotides that is substantially identical to SEQ ID NO: 3 and a second strand that is substantially complementary to the first.