Oral bioavailable prodrugs

摘要

The invention is directed to forming duplex prodrugs that provide significant increase in the transdermal flux of drugs across human skin. The prodrugs are prepared by reacting a drug that can form an ester moiety with phosgene to form a carbonate. The drug can be an opiate or an opiate antagonist. When in contact with human skin, the duplex drug is biotransformed by enzymes or by hydrolysis into two drug molecules.