Benzamide derivatives as p-38 kinase inhibitors

摘要

Benzamide combounds of Formula I: and their compositions for modulating the activity of p38 kinases are provided, including p38α, and p38&bgr; kinase. Methods for treating, preventing or ameliorating one or more symptoms of a p38 kinase mediated disease or disorder such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases are also provided.