发明名称 |
DERIVATIVES OF 4,6-DIMETHYL-2,3-DIHYDRO-1H-PYRAZOLO[4,3-c] PYRIDINE-3-ONES AND ETHERS 2,6-DIMETHYL-4-PHENYL-HYDRAZINE NICOTINIC ACIDS AS INTERMEDIATE PRODUCTS FOR THEIR SYNTHESIS, POSSESSING ANTIDEPRESSANT AND ANXIOLYTIC POTENCY |
摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to compounds having anxiolytic and antidepressant activity, which are derivatives of the formula 1 (a-b), or formula 2 (a-b) at that compounds of formula 2 (a-b) are intermediate products in synthesis of compounds of the formula , where R-Cl is a compound 1a or R'=COOC2H5 - compound 1b, , where R=COOC2H5 and R'=C1 - compound 2a; R=R-COOC2H5 - compound 2b. ^ EFFECT: obtaining new biologically active compounds that differ from analogues as intended in low toxicity and lack of side effects. ^ 5 cl, 3 ex, 5 tbl |
申请公布号 |
RU2394034(C2) |
申请公布日期 |
2010.07.10 |
申请号 |
RU20070115741 |
申请日期 |
2007.04.26 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT FARMAKOLOGIIIMENI V.V. ZAKUSOVA RAMN |
发明人 |
SEREDENIN SERGEJ BORISOVICH;VORONINA TAT'JANA ALEKSANDROVNA;GLOZMAN OLEG MIKHAJLOVICH;ZHMURENKO LJUDMILA ALEKSANDROVNA;MOLODAVKIN GENNADIJ MATVEEVICH;MELETOVA OL'GA KONSTANTINOVNA |
分类号 |
A61K31/4162;A61P25/24;C07D213/18;C07D471/04 |
主分类号 |
A61K31/4162 |
代理机构 |
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代理人 |
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地址 |
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