发明名称 |
RECOMBINANT EXPRESSION OF SELF-FOLDING NEUTRALIZING EPITOPE-BEARING SUBDOMAINS OF THE RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT AND FUSION PROTEINS |
摘要 |
The present invention is directed to self-folding, soluble, stable RSV G and F polypeptides that contain a neutralizing epitope. Fusion proteins and immunogenic conjugates containing the RSV G and F polypeptides, along with recombinant transgenes and vectors, and host cells suitable for expression of such genetic constructs are also disclosed. Use of the RSV G and F polypeptides, fusion proteins, immunogenic conjugates, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV. |
申请公布号 |
WO2010075491(A2) |
申请公布日期 |
2010.07.01 |
申请号 |
WO2009US69364 |
申请日期 |
2009.12.23 |
申请人 |
UNIVERSITY OF ROCHESTER;MURATA, YOSHIHIKO;WALSH, EDWARD, E. |
发明人 |
MURATA, YOSHIHIKO;WALSH, EDWARD, E. |
分类号 |
A61K39/12 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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