TGFP-CAP Peptide and its Uses

摘要

The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-&bgr;1 (transforming growth factor-&bgr;1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-&bgr;1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-&bgr;1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.