| 发明名称 |
METHODS OF QUANTIFYING METHOTREXATE METABOLITES |
| 摘要 |
The present invention provides a method for efficiently converting methotrexate polyglutamates to methotrexate in a cellular extract by contacting the cellular extract with gamma glutamyl hydrolase under conditions suitable for efficient conversion of methotrexate polyglutamates to methotrexate.
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| 申请公布号 |
US2010159493(A1) |
申请公布日期 |
2010.06.24 |
| 申请号 |
US20090484148 |
申请日期 |
2009.06.12 |
| 申请人 |
CYPRESS BIOSCIENCE, INC. |
发明人 |
DERVIEUX THIERRY;RICHERSON RUSSELL |
| 分类号 |
C12Q1/34;A61K35/18;C12Q1/37;G01N33/50 |
主分类号 |
C12Q1/34 |
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