发明名称 |
PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS |
摘要 |
<p>Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of aggluthination of the cells.</p> |
申请公布号 |
EP2198301(A1) |
申请公布日期 |
2010.06.23 |
申请号 |
EP20080830156 |
申请日期 |
2008.09.11 |
申请人 |
KODE BIOTECH LIMITED |
发明人 |
WEINBERG, CRISTINA-SIMONA;BOVIN, NICOLAI;HENRY, STEPHEN MICHEAL |
分类号 |
G01N33/539;A61K39/385;C07F9/10;C07K1/02;C07K1/04;C07K17/08;G01N33/53;G01N33/531;G01N33/536;G01N33/564;G01N33/68;G01N33/92 |
主分类号 |
G01N33/539 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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