发明名称 |
HUMANIZED ANTIBODIES AGAINST THE ß-AMYLOYD PEPTIDE |
摘要 |
The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerization of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed. |
申请公布号 |
EP2197914(A1) |
申请公布日期 |
2010.06.23 |
申请号 |
EP20080783482 |
申请日期 |
2008.09.15 |
申请人 |
DELENEX THERAPEUTICS AG;UNIVERSITY OF ZURICH |
发明人 |
EWERT, STEFAN;AUF DER MAUR, ADRIAN;CATTEPOEL, SUSANN;NITSCH, ROGER |
分类号 |
C07K16/18;A61K39/395;A61P25/28;G01N33/53 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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