REDUCING OR PREVENTING NEUROINFLAMMATION OR NEUROTOXICITY

摘要

Methods for the treatment of neuroinflammation or neurotoxicity are provided. For example, a method is provided for preventing neuroinflammation or neurotoxicity in a subject comprising administering to a subject an mGluR5 agonist. Also provided is a method of preventing neuroinflammation or neurotoxicity in a subject, wherein the subject has a central nervous system injury, comprising administering to the subject an mGluR5 agonist. Methods can further comprise preventing neuroinflammation or neurotoxicity in a subject, wherein the subject has or is suspected of having a neurodegenerative disease. The provided methods are useful for treating acute or chronic injury or disorder. For example, provided are methods of treating a subject having a nervous system disease or injury, comprising administering to the subject having the nervous system disease or injury an mGluR5 agonist.