发明名称 |
VACCINE FOR THE PREVENTION OF BREAST CANCER RECURRENCE |
摘要 |
Provided are methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the ?ER/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including patients having low to intermediate levels of HER2/neu expression. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. Also provided are vaccine compositions for use in the methods. |
申请公布号 |
WO2010068647(A1) |
申请公布日期 |
2010.06.17 |
申请号 |
WO2009US67264 |
申请日期 |
2009.12.09 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.;PEOPLES, GEORGE;PONNIAH, SATHIBALAN |
发明人 |
PEOPLES, GEORGE;PONNIAH, SATHIBALAN |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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