发明名称 |
ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP |
摘要 |
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level or a reduced serum albumin level prior to treatment. In another preferred embodiment, the patient's Glasgow Prognostic Score will be increased and survivability will preferably be improved. |
申请公布号 |
WO2010065072(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
WO2009US06257 |
申请日期 |
2009.11.24 |
申请人 |
ALDEN BIOPHARMACEUTICALS, INC.;SMITH, JEFFREY, T. L. |
发明人 |
SMITH, JEFFREY, T. L. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|