发明名称 OXAZOLIDINONE ANTIBIOTIC DERIVATIVES
摘要 The invention relates to antibacterial compounds of formula I wherein R1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent CH, one or two of U, V, W and X represent(s) N and the remaining each represent CH or, in the case of X, may also represent CRa, Ra being halogen, and, in the case of W, may also represent CRb, or each of U, V, W, X, Y1 and Y2 represents CH, or each of U, V, W, X and Y1 represents CH and Y2 represents N, or also one or, provided R1 is hydrogen, two of U, V, W, X, Y1 and Y2 represent(s) CRC and the remaining each represent CH, Rb being alkoxy, alkoxycarbonyl or alkoxyalkoxy and Rc being, each time it occurs, independently represents hydroxy or alkoxy; A-B-D represents a chain of 4 to 6 atoms, which 4 to 6 atoms are seleted from carbon, oxygen and nitrogen and may be substituted; E is one of the following groups: in which Z is CH or N and Q is O or S, or E is a phenyl group which is substituted once or twice in the meta and/or para position(s); and to salts of such compounds.
申请公布号 US2010137290(A1) 申请公布日期 2010.06.03
申请号 US20080595711 申请日期 2008.04.10
申请人 ACTELION PHARMACEUTICALS LTD. 发明人 GUDE MARKUS;HUBSCHWERLEN CHRISTIAN;RUEEDI GEORG;SURIVET JEAN-PHILIPPE;ZUMBRUNN-ACKLIN CORNELIA
分类号 A61K31/5415;A61K31/4375;A61K31/4709;A61K31/498;A61K31/517;A61K31/536;A61P31/04;C07D215/00;C07D241/36;C07D265/36;C07D279/16;C07D413/14;C07D471/02 主分类号 A61K31/5415
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