| 摘要 |
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from -C(R1)(R2)-, -C(R3)=, -N(R4)-, -N=, -N+(R5)=, -O- and -S-; M and Z are independently nondirectionally selected from formula (I) and formula (II). |
| 申请人 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER;GIESE, ARMIN;BERTSCH, UWE;KRETZSCHMAR, HANS;HABECK, MATHIAS;HIRSCHBERGER, THOMAS;TAVAN, PAUL;GRIESINGER, CHRISTIAN;LEONOV, ANDREI;RYAZANOV, SERGEY;WEBER, PETRA;GEISSEN, MARKUS;GROSCHUP, MARTIN, H.;WAGNER, JENS |
发明人 |
GIESE, ARMIN;BERTSCH, UWE;KRETZSCHMAR, HANS;HABECK, MATHIAS;HIRSCHBERGER, THOMAS;TAVAN, PAUL;GRIESINGER, CHRISTIAN;LEONOV, ANDREI;RYAZANOV, SERGEY;WEBER, PETRA;GEISSEN, MARKUS;GROSCHUP, MARTIN, H.;WAGNER, JENS |
