PYRROLOPYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE

摘要

A compound having the structure wherein, R1 is a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, -C(=O)NRaRb, -NRaRb, -NRaC(=O)NRaRb, -NRaC(=O)ORa, -OC(=O)NRaRb, or -NHC(=O)Ra; R2 is hydrogen or a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxyl, carboxyl, -C(=O)NRaRb, -NRaRb, -NRaC(=O)NRaRb, -NRaC(=O)ORa, -OC(=O)NRaRb, or -NHC(=O)Ra, or R1, R2 and N together form a substituted piperazine, substituted azetidine ring, or a pyrrolidine ring substituted with -(CH2)2OH or -CH2C(=O)OH; R3 is a substituted or unsubstituted phenyl or a 5-6 membered heteroaryl ring, wherein the substituent is halogen, hydroxyl, cyano, (C1-C15)alkyl, (C1-C15)alkoxyl, or -NRaRb; R4 is hydrogen or substituted or unsubstituted (C1-C15)alkyl; R5 is -(CH2)mOR6, -CHNOR7, -C(=O)NR8R9, -(CH2)mC(=O)OR10, -(CH2)kC(=O)NR11R12.