发明名称 |
METHOD FOR PRODUCTION OF ISOPRENOIDS |
摘要 |
The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds, while still producing sufficient squalene to allow the S. cerevisiae cells to grow without the requirement for supplementation by sterols such as ergosterol. These variant enzymes, therefore, are highly suitable for the efficient production of isoprenoids. |
申请公布号 |
WO2010019696(A3) |
申请公布日期 |
2010.05.14 |
申请号 |
WO2009US53589 |
申请日期 |
2009.08.12 |
申请人 |
ALLYLIX, INC.;JULIEN, BRYAN;BURLINGAME, RICHARD |
发明人 |
JULIEN, BRYAN;BURLINGAME, RICHARD |
分类号 |
C12N1/00;C12N1/19 |
主分类号 |
C12N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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