发明名称 Measurement of neural functionality using phase sensitive optical reflectometry
摘要 Optical methods, devices, and systems for non-invasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflection coatings are not required. Transient neural surface displacement of less than 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
申请公布号 US7711416(B1) 申请公布日期 2010.05.04
申请号 US20050136213 申请日期 2005.05.24
申请人 VOLCANO CORPORATION 发明人 AKKIN TANER;DAVE DIGANT P.;MILNER THOMAS E.;RYLANDER, III H. GRADY
分类号 A61B5/00 主分类号 A61B5/00
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