发明名称 |
Serum DNA Methylation Screening for Cancer |
摘要 |
We disclose a method of screening a mammal for a cancer associated with methylation of promoters of tumor-suppressor genes by collecting a sample of a body fluid or tissue of the mammal containing free DNA; isolating the free DNA from the sample; amplifying at least a portion of the promoter of each of a plurality of turner-suppressor genes associated with the cancer from the free DNA, to yield a plurality of amplified promoters; and quantifying methylation of each of the plurality of amplified promoters, to yield a methylation quantity. The method can have a high sensitivity and high specificity and can thus reduce the proportion of unneeded biopsies. It can also be performed with minimal invasiveness and discomfort to a patient.
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申请公布号 |
US2010099085(A1) |
申请公布日期 |
2010.04.22 |
申请号 |
US20070376148 |
申请日期 |
2007.07.30 |
申请人 |
BABAIAN RICHARD;FRITSCHE HERBERT;YANG LI-YING |
发明人 |
BABAIAN RICHARD;FRITSCHE HERBERT;YANG LI-YING |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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