FLUORINE-CONTAINING COMPOUND AND METHOD FOR DETECTING BIOMOLECULE USING THE SAME

摘要

The present invention provides an amphiphilic fluorine-containing compound having a structure represented by the following general formula (1) including a hydrophilic ligand Rl, a fluorine probe Rf, and linkers L1 and L2. In the formula, Rl is a hydrophilic ligand having a polar group; L2 is an alkylene group having one or more -CH2- which may independently be substituted by one of -NH-, -O-, -CO-, -SO2-, and an arylene group; Rf is selected from an alkyl group having one or more hydrogen atoms substituted by a fluorine atom and from an aryl group having at least one hydrogen atom substituted by one of F and a perfluoroalkyl group; m is selected from 0 and 1; and n is selected from 0 and 1. An aggregate including the compounds is destabilized through the binding to an enzyme. (1)