发明名称 |
DETECTION OF GRANULOSA-CELL TUMORS |
摘要 |
A method of detecting a granulosa-cell tumor is described herein. The method involves detecting a mutation in a sample derived from a subject, indicative of substitution of tryptophan in place of cysteine at amino acid position 134 of FOXL2 protein. The mutation may be detected as a DNA mutation 402C > G in the FOXL2 gene. Methods for screening for a granulosa-cell tumor from a blood-based assay are provided, as well as methods for making a determination that an ovarian tumor is not a granulosa-cell tumor. Kits for granulosa-cell tumors are described, and a method of treating a granulosa-cell tumor are also described.
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申请公布号 |
CA2740046(A1) |
申请公布日期 |
2010.04.15 |
申请号 |
CA20092740046 |
申请日期 |
2009.10.06 |
申请人 |
BRITISH COLUMBIA CANCER AGENCY BRANCH |
发明人 |
HIRST, MARTIN;HUNTSMAN, DAVID G.;MARRA, MARCO;MORIN, RYAN D.;SENZ, JANINE;SHAH, SOHRAB P. |
分类号 |
C12Q1/68;A61K38/17;A61K39/395;A61K45/00;A61K47/48;A61P35/00;C07K14/82;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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