发明名称 |
NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH |
摘要 |
PROBLEM TO BE SOLVED: To provide an improved method for chemically producing N-(13- methyltetradecyl)acetamide (capsiamide) which is an ingredient of Guinea pepper and has an analgesic action and an anti-inflammatory action. SOLUTION: This method for producing 13-methyltetradecylamine useful as an intermediate for synthesizing capsiamide, characterized by reacting a 5-halogenovaleronitrile as a starting raw material with triphenylphosphine, condensing the obtained phosphonium salt with 8-methyl-7-nonenal, and then reducing the obtained 13-cyano-2-methyltridecane-2,9-diene. The 13- methyltetradecylamine can be produced in a high yield. The method for producing the capsiamide, characterized by acetylating the 13-methyltetradecylamine with acetic anhydride. The capsiamide can be produced in a high yield. |
申请公布号 |
PL205150(B1) |
申请公布日期 |
2010.03.31 |
申请号 |
PL20010357568 |
申请日期 |
2001.02.14 |
申请人 |
TOYAMA CHEMICAL CO., LTD. |
发明人 |
EGAWA HIROYUKI;FURUTA YOUSUKE;SUGITA JUN;UEHARA SAYURI;HAMAMOTO SHOICHI;YONEZAWA KENJI |
分类号 |
A61K31/16;C07H19/04;A61K31/706;A61P29/00;A61P31/12;C07C209/48;C07C209/70;C07C211/07;C07C231/02;C07C233/05;C07C255/07;C07H19/20 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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