Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca Dimeric alkaloid precursors

摘要

The fluorinated derivatives of catharanthine according to the invention respond to the general formula I: in which: the dotted line expresses the possibility of the presence of a double bond when the substitution -X is absent or else a single bond when - X designates a substitution for a group: H, OR, NR'R'', SR, or a halogen atom with R, R' and R'' designating independently of one another a hydrogen atom or a linear or branched alkyl group in C1 to C6, R1, R2 and R3 represent independently of one another an atom of hydrogen, of fluorine or a methylated group, on the condition nevertheless that at least one of the radicals R1 and R2 represents an atom of fluorine, and n=1 or 2.I