发明名称 |
THERAPEUTIC AND DIAGNOSTIC STRATEGIES |
摘要 |
The present invention encompasses the finding that microRNAs (miRNAs) regulate certain key proteins involved in DNA repair. In some embodiments, a miRNA suppresses levels and/or activity of one or more DNA repair proteins. In some such embodiments, such suppression renders cells hypersensitive to certain DNA damage agents (e.g., ?-irradiation and genotoxic drugs, among others). The present invention provides various reagents and methods associated with these findings including, among other things, strategies for treating cell proliferative disorders, certain diagnostic systems, etc. |
申请公布号 |
WO2010033822(A2) |
申请公布日期 |
2010.03.25 |
申请号 |
WO2009US57506 |
申请日期 |
2009.09.18 |
申请人 |
IMMUNE DISEASE INSTITUTE, INC;LIEBERMAN, JUDY;LAL, ASHISH;CHOWDHURY, DIPANJAN |
发明人 |
LIEBERMAN, JUDY;LAL, ASHISH;CHOWDHURY, DIPANJAN |
分类号 |
A61K31/7105;A61P43/00;C12N15/11;C12N15/113 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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