发明名称 |
DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT |
摘要 |
<p>Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.</p> |
申请公布号 |
WO2010029469(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
WO2009IB53836 |
申请日期 |
2009.09.03 |
申请人 |
KONINKLIJKE PHILIPS ELECTRONICS N.V.;PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH;LANGEREIS, SANDER;KEUPP, JOCHEN;GRUELL, HOLGER;BURDINSKI, DIRK;BEELEN, DANIELLE |
发明人 |
LANGEREIS, SANDER;KEUPP, JOCHEN;GRUELL, HOLGER;BURDINSKI, DIRK;BEELEN, DANIELLE |
分类号 |
A61K49/06;A61K9/127;A61K49/18 |
主分类号 |
A61K49/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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