发明名称 |
Methods of using Fc-Cytokine fusion proteins |
摘要 |
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
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申请公布号 |
US2010068175(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20090411388 |
申请日期 |
2009.03.25 |
申请人 |
GILLIES STEPHEN D;LO KIN MING;WESOLOWSKI JR JOHN S |
发明人 |
GILLIES STEPHEN D.;LO KIN MING;WESOLOWSKI, JR. JOHN S. |
分类号 |
A61K38/20;A61K39/39;A61K38/16;A61K38/21;A61K39/00;A61K39/12;A61K39/21;A61K39/385;A61K39/44;A61P37/04;C07K14/16;C07K14/475;C07K14/52;C07K14/535;C07K14/705;C07K19/00;C12N15/62;G01N33/53 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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