发明名称 |
C-Type Lectin Fold as a Scaffold for Massive Sequence Variation |
摘要 |
This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.
|
申请公布号 |
US2010069300(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20090493802 |
申请日期 |
2009.06.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GHOSH PARTHO;MCMAHON STEPHEN;MILLER JASON;LAWTON JEFFREY |
分类号 |
A61K38/16;A61P35/00;C07H21/04;C07K14/42;C12P21/00;G01N33/53 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|