Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans,申请号EP20090010301-传众专利搜索

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发明名称	Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans
摘要	<p>The present invention is directed to processes for the synthesis of morphinans. In particular, a process tor coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl 3 that is necessary to form the 3,4-dihydroisoquinoline.</p>
申请公布号	EP2161253(A2)	申请公布日期	2010.03.10
申请号	EP20090010301	申请日期	2007.12.10
申请人	MALLINCKRODT INC.	发明人	GROTE, CHRISTOPHER W.;WANG, PETER X.;MOSER, FRANK W.;CANTRELL, GARY L.
分类号	C07C235/34;C07D217/20	主分类号	C07C235/34
代理机构		代理人
主权项
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