发明名称 |
ENHANCEMENT OF TRANSGENE EXPRESSION FROM VIRUS-BASED VACCINE VECTORS USING SUPPRESSORS OF THE TYPE 1 INTERFERON RESPONSE |
摘要 |
Baculovirus vectors with improved ability to express transgenes are provided. The baculovirus vectors are genetically engineered to contain and express nucleic acid sequences that encode one or more proteins that interfere with mammalian host cell type I interferon (IFN) responses. Thus, the expression of transgenes encoded by the baculovirus vector is not inhibited by a type I DFN response, and the transgenes are freely expressed in mammalian host cells. Alternatively, baculovirus vectors with nucleotide sequences encoding one or more genes of interest (e.g. tuberculosis or malarial antigens) are co-administered with one or more proteins that interfere with mammalian host cell type I IFN responses; or with viral vectors (e.g. adenovectors) that express one or more proteins that interfere with mammalian host cell type I IFN responses. |
申请公布号 |
WO2010025016(A2) |
申请公布日期 |
2010.03.04 |
申请号 |
WO2009US52969 |
申请日期 |
2009.08.06 |
申请人 |
AERAS GLOBAL TB VACCINE FOUNDATION;SADOFF, JERALD, C.;FULKERSON, JOHN;STONE, MICHELE |
发明人 |
SADOFF, JERALD, C.;FULKERSON, JOHN;STONE, MICHELE |
分类号 |
C12N15/866;A61K38/21;C12N15/20 |
主分类号 |
C12N15/866 |
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