发明名称 |
CYCLIC ANGIOTENSIN ANALOGS |
摘要 |
The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(1-8) agonistic or antagonistic activity and to cyclised Ang(1-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr4 and Pro7 in naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.
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申请公布号 |
US2010055146(A1) |
申请公布日期 |
2010.03.04 |
申请号 |
US20070376606 |
申请日期 |
2007.08.07 |
申请人 |
HAAS MARIJKE;KLUSKENS LEONARDUS DOROTHEA;KUIPERS ANNEKE;RINK RICK;NELEMANS SIEGER ADRIAAN;MOLL GERT NIKOLAAS |
发明人 |
HAAS MARIJKE;KLUSKENS LEONARDUS DOROTHEA;KUIPERS ANNEKE;RINK RICK;NELEMANS SIEGER ADRIAAN;MOLL GERT NIKOLAAS |
分类号 |
A61K9/00;A61K38/12;A61P9/00;C07K7/14 |
主分类号 |
A61K9/00 |
代理机构 |
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地址 |
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