发明名称 |
Heterocyclic N-Oxides as Hypoxic Selective Protein Kinase Inhibitors |
摘要 |
The invention relates to novel heterocyclic N-oxides which are useful as hypoxic selective cytotoxic agents that mediate and/or inhibit cell proliferation, for example, through the activity of protein kinases. The invention is further related to pharmaceutical compositions containing such compounds and compositions, and to methods of treating cancer as well as other disease states associated with unwanted ahgiogenesis and/or cellular proliferation by administering effective amounts of such compounds.
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申请公布号 |
US2010048540(A1) |
申请公布日期 |
2010.02.25 |
申请号 |
US20060815168 |
申请日期 |
2006.02.01 |
申请人 |
SENTINEL ONCOLOGY LIMITED |
发明人 |
BOYLE ROBERT GEORGE;TRAVERS STUART |
分类号 |
A61K31/551;A61K31/4709;A61K31/498;A61K31/5377;A61P35/00;C07D215/40;C07D215/48;C07D215/60;C07D239/94;C07D241/20;C07D241/54;C07D243/08;C07D401/04;C07D401/12;C07D401/14;C07D413/10;C07D471/04;C07D487/04 |
主分类号 |
A61K31/551 |
代理机构 |
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地址 |
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