发明名称 |
Buprenorphine formulations for intranasal delivery |
摘要 |
Aqueous formulations suitable for intranasal administration comprise buprenorphine or a physiologically acceptable salt or ester thereof and (a) a pectin having a degree of esterification of less than 50%, (b) chitosan and a polyoxyethylene-polyoxypropylene copolymer (poloxamer) or (c) chitosan and hydroxypropylmethylcellulose. Such formulations can induce rapid and prolonged analgesia when delivered intranasally to a patient. The buprenorphine or buprenorphine salt or ester may be delivered to the bloodstream to produce within 30 minutes a therapeutic plasma concentration of buprenorphine, Cther, of 0.2 ng/ml or greater which is maintained for a duration Tmaint of at least 2 hours.
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申请公布号 |
US7666876(B2) |
申请公布日期 |
2010.02.23 |
申请号 |
US20020508336 |
申请日期 |
2002.03.19 |
申请人 |
VERNALIS (R&D) LIMITED;ARCHIMEDES DEVELOPMENT LIMITED |
发明人 |
BIRCH PHILLIP JOHN;HAYES ANN GAIL;WATTS PETER JAMES;CASTILE JONATHAN DAVID |
分类号 |
A01N43/42;A61K9/08;A61F13/00;A61K9/00;A61K9/12;A61K31/195;A61K31/196;A61K31/35;A61K31/405;A61K31/407;A61K31/485;A61K31/54;A61K31/5415;A61K31/715;A61K45/00;A61K47/02;A61K47/10;A61K47/14;A61K47/18;A61K47/26;A61K47/34;A61K47/36;A61K47/38;A61M11/00;A61M15/08;A61P5/24;A61P15/00;A61P25/02;A61P25/04;A61P27/16;A61P29/00;A61P43/00;C07D498/00;C07D513/00;C07D515/00 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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