摘要 |
The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects. |
申请人 |
BASF SE;VAN RAVENZWAAY, BENNARD;MELLERT, WERNER;FABIAN, ERIC;STRAUSS, VOLKER;WALK, TILMANN, B.;LOOSER, RALF;LEIBOLD, EDGAR;KAMP, HENNICKE;COELHO PALERMO CUNHA, GEORGIA;HEROLD, MICHAEL, MANFRED;WIEMER, JAN, C.;PROKOUDINE, ALEXANDRE |
发明人 |
VAN RAVENZWAAY, BENNARD;MELLERT, WERNER;FABIAN, ERIC;STRAUSS, VOLKER;WALK, TILMANN, B.;LOOSER, RALF;LEIBOLD, EDGAR;KAMP, HENNICKE;COELHO PALERMO CUNHA, GEORGIA;HEROLD, MICHAEL, MANFRED;WIEMER, JAN, C.;PROKOUDINE, ALEXANDRE |