AMINO ACID AND PEPTIDE PRODRUGS OF OPIOID ANALGESICS WITH REDUCED GI SIDE-EFFECTS
摘要
The present invention relates to methods for reducing gastrointestinal side effects in a subject, the gastrointestinal side effects being associated with the administration of an opioid analgesic. The methods comprise orally administering an opioid prodrug or pharmaceutically acceptable salt thereof to a subject, wherein the opioid prodrug is comprised of an opioid analgesic covalently bonded through a carbamate linkage to a peptide of 1-5 amino acids in length, and wherein upon oral administration, the prodrug or pharmaceutically acceptable salt minimizes at least one gastrointestinal side effect associated with oral administration of the opioid analgesic alone. Compositions for use with the method are also provided.
申请公布号
WO2009092073(A3)
申请公布日期
2010.02.18
申请号
WO2009US31408
申请日期
2009.01.19
申请人
SHIRE LLC;FRANKLIN, RICHARD;GOLDING, BERNARD, T.;TYSON, ROBERT, G.
发明人
FRANKLIN, RICHARD;GOLDING, BERNARD, T.;TYSON, ROBERT, G.