A METHOD FOR PREPARING THIOFLAVANONE DERIVATIVES

摘要

PURPOSE: A method for preparing 2-phenylthiochroman-4-one derivative is provided to improvie yield of final product and without separation of chalcone compound. CONSTITUTION: A method for preparing thioflavanone(2-phenyl thiochroman-4-one) derivative comprises: a step of reacting methylation reagent with thiosalicylic acid to obtain 2'-mercaptoacetophenone; and a step of reacting benzealdehyde derivative to the 2'-mercaptoacetophenone to obtain 2-phenylthiochroman-4-one derivative. The methylation reagent is methyl lithium.