发明名称 |
SUBSTITUTED 2-ARYL-4-AMINO-QUINAZOLINES, METHODS FOR THE PRODUTION ANS USE THEREOF AS MEDICAMENTS |
摘要 |
Compounds of the formula I (see formula I) in which R1, R2, R3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and therapy of cardiovascular diseases such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance.
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申请公布号 |
CA2315205(C) |
申请公布日期 |
2010.02.02 |
申请号 |
CA19982315205 |
申请日期 |
1998.12.11 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
STROBEL, HARTMUT;SCHINDLER, URSULA;SCHONAFINGER, KARL;SCHINDLER, PETER |
分类号 |
C07D239/94;A61K31/517;A61P1/16;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P13/12;A61P15/10;A61P25/28;A61P43/00;C07D401/12;C07D403/12;C07D521/00 |
主分类号 |
C07D239/94 |
代理机构 |
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地址 |
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