THERAPEUTIC USES OF TRI-, TETRA-, PENTA-, AND POLYPEPTIDES

摘要

NOVEL USES OF CERTAIN PEPTIDES TO TREAT PATIENTS SUFFERING FROM NEUROLOGICAL OR PSYCHIATRIC DISORDERS ARE DISCLOSED. THE PEPTIDES INCLUDE THE TRIPEPTIDE HORMONE MIF AND COMPOUNDS MADE BY MODIFICATIONS OF MIF, SUCH AS MODIFICATION OF AMINO TERMINUS RESIDUES, CARBOXYL TERMINUS RESIDUES AND INTERNAL RESIDUES, INCLUDING ADDITION AND SUBSTITUTION OF AMINO ACID RESIDUES AND MODIFICATION OF THE PEPTIDE BONDS AND FUNCTIONAL SIDE GROUPS OF RESPECTIVE AMINO ACID RESIDUES. THE TRI-, TETRA-, PENTA-, PEPTIDES AND POLYPEPTIDES MAY BE UTILIZED ALONE OR IN COMBINATION WITH OTHER AGENTS, TO TREAT PATIENTS SUFFERING FROM PHYSIOLOGICAL, PSYCHOSOMATIC, NEUROLOGICAL OR PSYCHIATRIC DISORDERS.