| 发明名称 |
G-PROTEIN COUPLED RECEPTOR 30 (GPR30) KNOCKOUT MICE AS A MODEL FOR CARDIOVASCULAR DISEASES |
| 摘要 |
<p>The present invention relates to use of the GPR30 gene for diagnosis and treatment of cardiovascular disorders, especially cardiomyopathy. The present invention also relates to a GPR30 deficient animal model, more specifically to a mouse in which the GPR30 gene is disrupted and which exhibits a cardiomyopathy, a tissue and a cell of the mouse and a process of producing the same. The present invention further relates to use of said knockout mouse as a model of cardiovascular diseases, especially cardiomyopathy, and a method of screening a compound useful for the prevention and/or treatment of cardiovascular diseases, especially cardiomyopathy, using the knockout mouse.</p> |
| 申请公布号 |
WO2010006703(A1) |
申请公布日期 |
2010.01.21 |
| 申请号 |
WO2009EP04769 |
申请日期 |
2009.07.02 |
| 申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT;KLEIN, MARTINA;GOLZ, STEFAN;SCHAEFER, STEFAN;OTTO, CHRISTIANE |
发明人 |
KLEIN, MARTINA;GOLZ, STEFAN;SCHAEFER, STEFAN;OTTO, CHRISTIANE |
| 分类号 |
C12N15/85;A01K67/027;A61K49/00;G01N33/50 |
主分类号 |
C12N15/85 |
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