| 发明名称 |
Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors |
| 摘要 |
Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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| 申请公布号 |
US7648986(B2) |
申请公布日期 |
2010.01.19 |
| 申请号 |
US20070733045 |
申请日期 |
2007.04.09 |
| 申请人 |
BAYER HEALTHCARE LLC |
发明人 |
NAGARATHNAM DHANAPALAN;KHIRE UDAY;ASGARI DAVOUD;SHAO JIANXING;LIU XIAO-GAO;WANG CHUNGUANG;HART BARRY;WEBER OLAF;LYNCH MARK;ZHANG LEI;WANG LEI |
| 分类号 |
C07D491/048;C07D495/04;A61K31/496;A61K31/497;A61K31/498;A61K31/519;A61K31/53;A61K31/5377;A61P7/02;A61P9/10;A61P9/12;A61P11/06;A61P15/10;A61P19/10;A61P25/00;A61P27/06;A61P35/00;A61P35/04;A61P43/00;C07D251/16;C07D401/12;C07D401/14;C07D413/10;C07D471/04;C07D491/04 |
主分类号 |
C07D491/048 |
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