| 摘要 |
<p>A method and apparatus of resource management for multimedia broadcast multicast services (MBMS) are disclosed. A wireless transmit/receive unit (WTRU) sends a measurement report and an MBMS reception performance report to a network. Single frequency network (SFN) area change may be made based on cell reselection information, WTRU macro-diversity MBMS reception performance, neighbor cell signal strength reported by a WTRU, interference level measured by the WTRU, a number of WTRUs in a cell, service priority, WTRU class, WTRU mobility trend, WTRU location to a cell center, WTRU MBMS reception interference level, etc. The MBMS service on/off decision and/or point-to-point (PTP) to point-to-multipoint (PTM) switching may be made based on a channel condition of a WTRU. The channel condition may be determined based on whether the WTRU is in in-sync or out-of-sync in MBMS reception, consecutive negative acknowledgements (NAKs) within a certain time window, measured pathloss from a reference channel, etc. A method and apparatus of resource management for multimedia broadcast multicast services (MBMS) are disclosed. A wireless transmit/receive unit (WTRU) sends a measurement report and an MBMS reception performance report to a network. Single frequency network (SFN) area change may be made based on cell reselection information, WTRU macro-diversity MBMS reception performance, neighbor cell signal strength reported by a WTRU, interference level measured by the WTRU, a number of WTRUs in a cell, service priority, WTRU class, WTRU mobility trend, WTRU location to a cell center, WTRU MBMS reception interference level, etc. The MBMS service on/off decision and/or point-to-point (PTP) to point-to-multipoint (PTM) switching may be made based on a channel condition of a WTRU. The channel condition may be determined based on whether the WTRU is in in-sync or out-of-sync in MBMS reception, consecutive negative acknowledgements (NAKs) within a certain time window, measured pathloss from a reference channel, etc. The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.</p> |
