ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

摘要

The invention relates to antineoplastic compounds of formula (I) where: - R1 is a (C3-C7)cycloalkyl or (C1-C6)alkyl group optionally substituted with -NRaNb; - A is -NR2N3; - B is -NR4R5 or -OR6; R6 is H or a (C1-C4)alkyl group; - Z is N or CH, and Z' is N or CH if Z is N and CH if Z is CH; - R7 is H or a (C1-C4) alkyl group; - L is a -CH=CH-, -CH2CH2-, -CH2CH[NHC(=O)O(C1-C4)alkyl]], or -(CH2)n-Y- group (n=1-4, and y = O or NR8, with R8 being H or a (C1-C4)alkyl group); - Ar is a group chosen from formula (II).