发明名称 |
VACCINE FOR PORCINE POST-WEANING DIARRHEA CAUSED BY ENTEROTOXIGENIC ESCHERICHIA COLI |
摘要 |
Vaccines and methods for making and using the same. An example vaccine may be a vaccine against enterotoxigenic Escherichia coli. The vaccine may include an Escherichia coli strain. The Escherichia coli strain may produce K88 fimbria and a fusion protein including a mutant LT enterotoxin linked with a STb enterotoxin. An example method for producing a vaccine for porcine post-weaning diarrhea may include providing a first strain of Escherichia coli. The strain may include the eltAB gene and the estB gene. The method may also include amplifying the eltAB gene, mutating the eltAB gene, generating a genetic fusion of the mutant eltAB gene with the estB gene, and transforming a second strain of Escherichia coli with the genetic fusion.
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申请公布号 |
US2010008949(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
US20080169259 |
申请日期 |
2008.07.08 |
申请人 |
SOUTH DAKOTA STATE UNIVERSITY |
发明人 |
FRANCIS DAVID;ZHANG WEIPING |
分类号 |
A61K39/00;A61P37/00;C12N15/87 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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